Bacterial Drug Efflux Proteins.
نویسندگان
چکیده
منابع مشابه
Assembly and Channel Opening in a Bacterial Drug Efflux Machine
Drugs and certain proteins are transported across the membranes of Gram-negative bacteria by energy-activated pumps. The outer membrane component of these pumps is a channel that opens from a sealed resting state during the transport process. We describe two crystal structures of the Escherichia coli outer membrane protein TolC in its partially open state. Opening is accompanied by the exposure...
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Bacteria such as Escherichia coli and Pseudomonas aeruginosa expel antibiotics and other inhibitors via tripartite multidrug efflux pumps spanning the inner and outer membranes and the intervening periplasmic space. A key event in pump assembly is the recruitment of an outer membrane-anchored TolC exit duct by the adaptor protein of a cognate inner membrane translocase, establishing a contiguou...
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ژورنال
عنوان ژورنال: Nippon Saikingaku Zasshi
سال: 1995
ISSN: 1882-4110,0021-4930
DOI: 10.3412/jsb.50.403